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Latest Article
Effect of Zingiber Officinale Ethanol Extract on Reproductive Hormones...
0

Cyril Onyekachi Edoga*, Okoh,...
Department of Applied Biology and Biotechnology, Enugu State University of Science and Technology (ESUT), Enugu Nigeria
7-11
https://doi.org/10.5281/zenodo.18798260

Reproductive function is known to be disrupted by inflammation, and Zingiber officinale, has long been used to treat inflammatory diseases. In this work, male albino Wistar rats with albumin-induced inflammation were used to assess the modulatory effects of Zingiber officinale ethanol extract on reproductive hormones, such as testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH). A control group, an inflammation-induced group, and groups treated with different dosages of Zingiber officinale ethanol extract comprised the five (5) groups of thirty (30) male albino Wistar rats. Albumin was used to cause inflammation, and the extract was taken orally for three weeks. Standard laboratory methods, such as enzyme-linked immunosorbent assay (ELISA) and radioimmunoassay (RIA), were used to evaluate hormone levels. The results showed that Zingiber officinale ethanol extract significantly modulated reproductive hormone levels in the treated groups compared to the control groups. Specifically, testosterone levels increased (14.39 ± 0.0003), while FSH and LH levels showed dose-dependent responses. The findings suggest that Zingiber officinale ethanol extract may have a regulatory effect on reproductive hormone production in male albino Wistar rats with albumin-induced inflammation, potentially due to its anti-inflammatory and antioxidant properties. These results have potential implications for the treatment of reproductive disorders associated with inflammation and warrant further investigation into the mechanisms underlying the modulatory effects of Zingiber officinale on reproductive hormones.
Effect of Zingiber Officinale Ethanol Extract on Renal Functions of Ma...
0

Cyril Onyekachi Edoga*, Ezema,...
Department of Applied Biology and Biotechnology, Enugu State University of Science and Technology (ESUT), Enugu Nigeria
1-6
https://doi.org/10.5281/zenodo.18798143

This study evaluated the effect of ethanol extract of Zingiber officinale on renal function markers in male Wistar albino rats subjected to albumin-induced inflammation. The animals were divided into five groups: blank control, negative control (inflammation without treatment), standard control (treated with a reference anti-inflammatory drug), and two treatment groups administered low and high doses of Z. officinale extract. Renal function was assessed through serum creatinine, urea, calcium (Ca), and chloride (Cl⁻) levels. The negative control group exhibited significantly elevated levels of creatinine (0.59±0.00 mg/dl), urea (12.22±0.001 mg/dl), and calcium (6.93±0.11 ppm), alongside a sharp reduction in chloride (4.42±0.00 ppm), compared to the blank control (p < 0.05), indicating renal impairment caused by inflammation. Treatment with high-dose Z. officinale extract significantly restored creatinine (0.52±0.00 mg/dl), urea (11.02±0.03 mg/dl), calcium (5.33±0.13 ppm), and chloride (7.54±0.11 ppm) levels to values comparable to the standard control and blank groups (p > 0.05), while the low-dose treatment showed only partial improvement. These findings demonstrate that Zingiber officinale ethanol extract, particularly at high doses, possesses nephroprotective properties, mitigating inflammation-induced renal dysfunction and restoring electrolyte balance.
Effect of Zingiber Officinale Ethanol Extract on Serum Electrolytes of...
0

Cyril Onyekachi Edoga*, Okoh,...
Department of Applied Biology and Biotechnology, Enugu State University of Science and Technology (ESUT), Enugu Nigeria
77-82
https://doi.org/10.5281/zenodo.18797248

This study investigated the effect of Zingiber officinale ethanol extract on serum electrolyte concentrations in male Wistar albino rats exposed to inflammation. Rats were randomly divided into five groups: Group A (blank control), Group B (negative control with induced inflammation and no treatment), Group C (standard control treated with a conventional anti-inflammatory drug), Group D (low-dose Zingiber officinale extract), and Group E (highdose Zingiber officinale extract). Serum levels of sodium (Na⁺), potassium (K⁺), chloride (Cl⁻), and calcium (Ca²⁺) were analyzed to assess the impact of treatments. The results revealed that inflammation significantly reduced serum electrolyte levels in the negative control group (B), with marked low sodium ion concentration (87 ± 0.008 mmol/L), low potassium ion concentration (2.2 ± 0.001 mmol/L), depleted level of chloride ion (57.40 ± 0.000 mmol/L), and low calcium ion concentration (2.2 ± 0.000 mg/dL) compared to the blank control group (A), all at p < 0.05. Administration of low-dose Zingiber officinale extract (Group D) showed no significant improvement in these electrolyte levels when compared to the negative control (p > 0.05). However, treatment with high-dose Zingiber officinale extract (Group E) significantly improved serum concentrations of Na⁺ (117 ± 0.003 mmol/L), K⁺ (5.6 ± 0.001 mmol/L), Cl⁻ (98.0 ± 0.004 mmol/L), and Ca²⁺ (4.4 ± 0.003 mg/dL), indicating a dose-dependent restorative effect. These findings inferred that high-dose Zingiber officinale ethanol extract may have restored electrolyte balance in inflammatory conditions, potentially serving as a natural therapeutic agent.
Effect of Zingiber officinale Ethanol Extract on Neurohormone Concentr...
0

Cyril Onyekachi Edoga*, Nweke,...
Department of Applied Biology and Biotechnology, Enugu State University of Science and Technology (ESUT), Enugu Nigeria
71-76
https://doi.org/10.5281/zenodo.18797125

This study investigated the effect of ethanol extract of Zingiber officinale on neurohormone concentrations in male Wistar albino rats subjected to albumin-induced inflammation. Inflammation was induced to evaluate the alterations in key neurohormones, dopamine, oxytocin, corticotropin, and norepinephrine, and assess the modulatory role of Z. officinale. Rats were grouped into blank control, negative control (inflammation without treatment), standard control (treated with ibuprofen), and two experimental groups treated with low and high doses of Z. officinale extract. The results revealed a significant decrease (p < 0.05) in dopamine, oxytocin, corticotropin, and norepinephrine levels in the negative control group (339±0.001, 5.60±0.001, 5.16±0.031, and 11.12±0.004, respectively) compared to the blank control, indicating the suppressive effect of inflammation on neurohormonal activity. However, treatment with Z. officinale, particularly at high doses, significantly restored these neurohormones toward normal levels, showing values statistically comparable to the standard control group (p > 0.05). These findings demonstrate that Zingiber officinale ethanol extract possesses neuroprotective and anti-inflammatory properties capable of reversing inflammationinduced neurohormonal disruptions. The study highlights Zingiber officinale’s potential as a natural therapeutic agent for managing neuroinflammatory conditions.
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