This systematic review aimed to consolidate research on the relationship between family dynamics and parental adjustment in families raising children with disabilities. Studies published between 2000 and 2022 were included, focusing on various disabilities and global contexts. A total of 42 studies were reviewed, employing quantitative, qualitative, and mixedmethods designs. Four main themes were identified: communication patterns, support systems, role distribution, and family cohesion. Effective communication emerged as a key factor, contributing to reduced parental stress and improved parental adjustment. Support systems, including family, friends, peer networks, and professional services, played a critical role in alleviating caregiving burdens and fostering adjustment. Families with clearly defined roles experienced better adaptation, while role ambiguity often led to heightened stress and poor adjustment. Family cohesion also emerged as essential, with cohesive families engaging in collaborative problem-solving, enhancing parental adjustment. These findings emphasized the importance of interventions focused on improving communication, strengthening support networks, clarifying roles, and promoting family cohesion to enhance parental well-being and caregiving effectiveness in families raising children with disabilities.