The study examined the effectiveness of Home Economics students in entrepreneurship in Federal College of Education, Abeokuta. Home Economics entrepreneurship education is acclaimed the world over as education for the acquisition of skills for gainful employment. Such education is designed to satisfy the manpower needs of a particular nation. The study adopted casual expost-facto research which allowed for collection of data in a relatively short period of time. The population of the study comprises of 120 students in NCE II (220) and NCE III (320) offered entrepreneurship courses in 2018/19, 2019/20, 2020/21 and 2021/22 session. Ten (10) lecturers from Vocational Education was used to provide insights into curriculum effectiveness and instructional methods. The students’ scores obtained in academic sessions were moderated scores by the external examiners making the instruments valid and reliable for the research. Data collected in relation to the research questions were analysed using frequency count and percentages. The study is significant in strengthening entrepreneurship education among Home Economics students which led in business creation, innovation and job opportunities contributing to economic growth. The study revealed that 49 or 22.6% of the candidates for HEC 220 scored below 50% while 22 or 8.4% of the candidates for HEC 320 scored below 50% at the academic session. This implied that 300 level students performed better than 200 level counterparts in the domesticated entrepreneurship courses in 2018/19, 2019/20 session. HEC 220, the candidates scored below 50% while 56 or 27% of the candidates for the HEC 220 scored below 50% at the end of the session. This indicated that 200 level students performed actively well than their 300 level counterparts in the entrepreneurship courses. The study recommended that identified entrepreneurship courses should be domiciled in the department using appropriate practical entrepreneurship courses boosting the living standards of citizens contributing to national economic development.