Methods: A cross-sectional analytical study was conducted among 150 clinically diagnosed hypertensive adults. Sociodemographic, lifestyle, and clinical data were collected using structured questionnaires. ABO and Rh blood grouping were performed using standard methods, while blood pressure classifications followed WHO and ACC/AHA guidelines. Chisquare tests assessed associations between blood groups and hypertension categories, and binary logistic regression evaluated the predictive influence of age, sex, and BMI. Results: Blood group O was the most prevalent (70.7%), followed by B (18.0%), A (10.0%), and AB (1.3%). Most participants (68.7%) were classified as having Stage 2 hypertension despite ongoing treatment. Chi-square analysis showed no significant association between ABO blood groups and hypertension categories (χ² = 8.647, p = 0.470). Logistic regression revealed that sex (p = 0.592), age (p = 0.766), and BMI (p = 0.785) were not significant predictors of hypertension within the sample. Conclusion: The distribution of ABO blood groups among hypertensive patients largely mirrored the general Ghanaian population, and no significant association was found between blood group type and hypertension severity. Demographic variables also showed no predictive value. These findings suggest that ABO blood group typing does not contribute to hypertension risk stratification in this setting. Efforts should instead focus on addressing modifiable lifestyle and metabolic risk factors.