Cell-to-cell communication is exploited by a wide range of bacteria in order to monitor the density of their population, synchronize their behavior, and participate in social contact with one another. In the end, coordinated gene regulation will develop as a consequence of this mode of communication, which is more popularly known as quorum sensing. Acylated homoserine lactones, also known as AHLs, are the quorum signal molecules that are found in gram-negative bacteria the majority of the time. Alternative low-molecular-mass signaling molecules, such as Autoinducer-2 (AI-2), have also been reported. Nevertheless, these molecules have been reported. AHL-regulated Serratia phenotypes are diverse, biologically and ecologically important, and often braided with other global regulators. This is because AHLs are responsible for interacting with other global regulators. The reason for this is because AHLs are the ones that are in charge of controlling these actions. Additionally, AHL- and AI-2-mediated mechanisms, which have been explored to a lesser extent, are continuously being identified and researched when it comes to Serratia species. There are a lot of these systems that offer fascinating variations on the primary content. The goal of this review is to concentrate on the quorum sensing systems that are now known to exist in Serratia species, including the major nosocomial pathogen Serratia marcescens. This review will be conducted in order to achieve this conclusion.