In this study, we investigated the extents to which crypto-currencies practices influence business performance by focusing on online shopping firms in Nigeria. The study used three (3) traded crypto-currencies – Bitcoin, Etherum and the United States Dollar Tether; hence, the independent variable is crypto-currencies practices while the dependent variable is business performance. A survey one hundred and thirty-three (133) crypto-exchangers who had traded crypto-currencies like Bitcoin, Ethereum and the United States Dollar Tether were sampled. The questionnaires administered were analyzed using descriptive, regression diagnostic and inferential statistical techniques. The multiple regression results revealed among others that there is significant relationship between crypto-currencies practices (Bitcoin, Ethereum and the United States Dollar Tether)and the performance of online shopping firms. Hence, performance of online shopping firms partly depends on crypto-currencies practices. In view of the findings, the study recommends among others that the Nigerian government via the Central Bank of Nigeria should regulate, control and encourage the practices of cryptocurrencies by using the global digital financing system software; this software would help monitor crypto-currency practices and be able to attract more crypto –exchangers, which will in turn contribute to increased economic activities and business performance in Nigeria.