In the context of the strong fourth industrial revolution, Ca Mau province has determined that the digital transformation is a key task to promote sustainable socio -economic development. The province has issued many important policies such as Resolution 05-NQ/TU and Decision 1929/QD-UBND, set goals to 2025 basically completing digital areas, towards digital economy accounting for 20% GRDP in 2030. The outstanding result is Ca Mau's digital conversion index of 23 levels nationwide, with many achievements in deploying digital, digital and digital economy. The conversion of the whole political system, developing digital infrastructure, and applying information technology to management has brought practical benefits to people and businesses. However, Ca Mau still faces challenges such as inconsistent infrastructure, limited number of human resources and uneven social awareness. The article proposes a number of key solutions such as raising awareness, investing infrastructure, training human resources and streamlining the government apparatus to continue promoting the effectiveness of digital transformation, contributing to building a modern economy, civilized society and strong defense and security in digital era.