Serum protein profiles, such as total protein, albumin, and globulin fractions, are frequently altered by inflammation and can be used as indicators for systemic immune response and hepatic function. Ginger, or Zingiber officinale, has long been used to treat a variety of inflammatory disorders due to its well-known anti-inflammatory and antioxidant qualities. This study examined the effects of Zingiber officinale extracts on serum proteins in male albino wistar rats that had been inflamed. Five (5) groups of rats were created: blank control, negative control, standard control, low-dose extract, and high-dose extract. With the exception of the blank control group, all groups were induced with inflammation. Serum protein activities including total protein, albumin, alpha-globulin, beta-globulin globulin and total globulin were evaluated following the 21-day experiment. With the exception of total protein, which had lower levels, the generated inflammation markedly raised serum protein activities, indicating toxicity. With the exception of total protein, where it boosted activity, Zingiber officinale ethanol extract dramatically lowered serum protein levels to normal levels, indicating protection. The albumin levels were shown to be reduced in a dose-dependent manner. When the high dose (6.44 ± 0.000) was compared to the blank control (5.51 ± 0.001), the negative control (17.57 ± 0.00) showed the greatest reduction (p<0.05), followed by the standard control (14.69 ± 0.011). These results suggested that Zingiber officinale ethanol extracts could be used as a medicinal treatment since they could reduce inflammation-induced toxicity