Reproductive function is known to be disrupted by inflammation, and Zingiber officinale, has long been used to treat inflammatory diseases. In this work, male albino Wistar rats with albumin-induced inflammation were used to assess the modulatory effects of Zingiber officinale ethanol extract on reproductive hormones, such as testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH). A control group, an inflammation-induced group, and groups treated with different dosages of Zingiber officinale ethanol extract comprised the five (5) groups of thirty (30) male albino Wistar rats. Albumin was used to cause inflammation, and the extract was taken orally for three weeks. Standard laboratory methods, such as enzyme-linked immunosorbent assay (ELISA) and radioimmunoassay (RIA), were used to evaluate hormone levels. The results showed that Zingiber officinale ethanol extract significantly modulated reproductive hormone levels in the treated groups compared to the control groups. Specifically, testosterone levels increased (14.39 ± 0.0003), while FSH and LH levels showed dose-dependent responses. The findings suggest that Zingiber officinale ethanol extract may have a regulatory effect on reproductive hormone production in male albino Wistar rats with albumin-induced inflammation, potentially due to its anti-inflammatory and antioxidant properties. These results have potential implications for the treatment of reproductive disorders associated with inflammation and warrant further investigation into the mechanisms underlying the modulatory effects of Zingiber officinale on reproductive hormones.