This study investigated the effect of ethanol extract of Zingiber officinale on neurohormone concentrations in male Wistar albino rats subjected to albumin-induced inflammation. Inflammation was induced to evaluate the alterations in key neurohormones, dopamine, oxytocin, corticotropin, and norepinephrine, and assess the modulatory role of Z. officinale. Rats were grouped into blank control, negative control (inflammation without treatment), standard control (treated with ibuprofen), and two experimental groups treated with low and high doses of Z. officinale extract. The results revealed a significant decrease (p < 0.05) in dopamine, oxytocin, corticotropin, and norepinephrine levels in the negative control group (339±0.001, 5.60±0.001, 5.16±0.031, and 11.12±0.004, respectively) compared to the blank control, indicating the suppressive effect of inflammation on neurohormonal activity. However, treatment with Z. officinale, particularly at high doses, significantly restored these neurohormones toward normal levels, showing values statistically comparable to the standard control group (p > 0.05). These findings demonstrate that Zingiber officinale ethanol extract possesses neuroprotective and anti-inflammatory properties capable of reversing inflammationinduced neurohormonal disruptions. The study highlights Zingiber officinale’s potential as a natural therapeutic agent for managing neuroinflammatory conditions.