This study investigates the factors influencing women’s entrepreneurship and selfreliance as a panacea to combating unemployment in Nigeria, focusing on selected entrepreneurs in Ondo State. Through a qualitative research design, the study utilizes interviews and surveys to gather insights from a diverse range of women-led businesses, from small-scale enterprises to larger ventures. Findings reveal that women entrepreneurs encounter significant challenges, such as limited access to finance, inadequate training, and societal barriers. Despite these obstacles, their contributions to job creation and economic development are considerable, with many women entrepreneurs achieving self-reliance and creating employment opportunities within their communities. The study underscores the need for supportive government policies that improve access to funding, training, and resources tailored for women entrepreneurs. Recommendations include establishing microfinance institutions, implementing targeted training programs, and fostering networking opportunities to promote collaboration among women entrepreneurs. Ultimately, this research highlights that empowering woman through entrepreneurship addresses unemployment while promoting economic growth and social development in Nigeria. By presenting successful case studies, the study demonstrates the transformative potential of women’s entrepreneurship in combating unemployment in the region.