This study focused on factors influencing Ghana School Feeding Programme (GSFP) Enrolment and Retention in Pru East District, Ghana. The research employed positivist research paradigm. The present research used descriptive cross sectional research design with quantitative research approach to collect data for the study. Also, the study population were SHEP coordinator, GSFP Desk Officer, headteacher and teachers of beneficiary school feeding schools within Pru East district. The sample size of the research was 120 respondents comprising 96 teachers, 22 headteacher, 1 SHEP Coordinator and 1 Desk Officer. The researchers used purposive sampling method to select the headteachers, SHEP coordinator, GSFP desk officer while simple random sampling method was used to select the teachers for the study using lottery method. The instrument employed to collect data for the study was closed-ended questionnaire designed by the researcher. Data collected from the field for this study was captured, edited, coded and analyzed using the Statistical Package for Social Sciences (SPSS v20) software programme into simple frequencies, percentages, means and standard deviation. The present finding revealed that GSFP increased enrollment in schools in Pru East district with (M=1.51; Std= 0.98) and 103(90%) of the respondents confirmed the assertion. Also, the present finding revealed that the major challenge confronting the GSFP was high caterer?s turnover with (M=1.17, SD=1.12) and 101(84.2%) of the respondents confirmed the assertion. However, the study concluded that enrollment of school continue to increase since the introduction of the GSFP in the district and there is a need to increase the number to cover more school for all children to benefit equally. The study recommended that Government should timely release fund for payment of caterers to avoid high caterers turn-over rate.