This study is set out to examine the influence of gender on the readership of sports pages of mainstream newspapers in Uyo. The objectives of the study are to: determine the extent to which residents of Uyo read sports pages of mainstream newspapers; ascertain whether gender influences readership of sports pages of mainstream newspapers in Uyo; discover the extent to which gender influences readership of sports pages of mainstream newspapers in Uyo. In giving the study a theoretical underpinning, the Individual Differences and Uses and Gratifications theories were theorized. The survey research design was adopted for the collection of data. The population of the study comprised 487,887 as projected in the year 2024, with a sample size of 381 respondents drawn out of the population using Taro Yamane?s formula. Using the multi-stage sampling procedures, respondents were selected across areas in Uyo. The findings revealed that most of the respondents read sports pages to a very great extent and that gender influences sports page consumption patterns. Other influencing variables that are affecting readership to a significant extent include the credibility of content, need for information, availability, and headline. The results suggest that sports page production should consider gender differences along with presenting credible and information-rich material with captivating headlines. Any improvement in availability may further increase readership. The study recommended among others that the planning of sports pages needs to be done in such a way that it gives significance to gender differences for greater readership.