Urban regeneration of deteriorated fabrics remains one of the most pressing challenges in contemporary urban planning and architectural practice. This paper presents a systematic integrative review examining the nexus between housing empowerment strategies and social innovation frameworks in facilitating sustainable urban regeneration. Drawing upon 47 peer-reviewed articles published between 2009 and 2025, this study synthesizes evidence from diverse geographical contexts—including Europe, Africa, and the Middle East—to construct a comprehensive conceptual framework. The findings reveal that successful regeneration initiatives are contingent upon three interdependent pillars: (1) physical retrofitting of existing housing stock, (2) socially innovative governance mechanisms that foster resident participation, and (3) integrated policy instruments that bridge economic viability with social equity. The paper contributes to the theoretical discourse by proposing a multi-scalar empowerment model (MSEM) that operationalizes the transition from top-down renewal to participatory regeneration. Implications for policy, practice, and future research are discussed.