Food hygiene is a vital part of everyday life everywhere, impacting both producers and consumers. In most low- to middle-income countries, it has become one of the most challenging issues to deal with. A 2015 World Health Organization research estimates that 420,000 people die from food-borne illnesses each year, and that the global burden of food-borne illnesses is over 600 million cases, or over one in ten individuals. The goal of this study was to assist in improving food-related disease prevention measures at the Ministry of Public Health and Community level. A community-based cross-sectional study using systematic random sampling was the design of the investigation. Mvog-Betsi Market, one of the food vending marketplaces in Cameroon's Center Region, served as the study region. A semi-structured questionnaire including four sections of closed and open-ended questions with predetermined objectives served as the data gathering method. SPSS (Statistical Package for Social Sciences) version 20 statistical software was used to analyze the data, which was then displayed as a frequency distribution table, pie charts, and bar charts. 81.8% of the 110 respondents that were enlisted for the study were female, and 18.2% were male, according to data collection and analysis. Given that they make up the majority, women are in charge of handling matters pertaining to food. Sixty-seven percent of the food vendors knew what food hygiene was. In terms of practice, the current study reveals that just 25.6% of respondents follow good food hygiene, while 74.4% do not. The majority of food vendors had poor food hygiene practices, although having strong knowledge of food hygiene, it may be concluded. The government should regulate vending activities and create training programs to educate sellers about food safety and hygiene, according to this finding.