Gender and sexual minorities (GSM) face significant discrimination, stigma, and marginalization, which can lead to negative mental health outcomes, including suicidal ideation. This study examined the relationship between minority stressors (microaggressions, perceived stigma, and internalized homophobia) and suicidal ideation among gender and sexual minorities in Cross River State. Additionally, the moderating role of perceived family support on this relationship was investigated. A cross-sectional survey design was used to collect data from a sample of 129 gender and sexual minority individuals. Data were collected using the following instruments: the LGBTQ+ Microaggressions Scale (LMS), the Gender and Sexual Minority Stigma Scale (GSMSS), the Internalized Homophobia Scale (IHS), and the Beck Scale for Suicidal Ideation (BSS). Perceived family support was measured using a modified version of the Family Support Scale. Data were analyzed using hierarchical multiple regression analysis, with perceived family support entered as a moderator variable. The results showed that microaggressions did not significantly predict suicidal ideation (β = -.070; t = -.91; P >.05). However, perceived stigma (β =.17; t = 2.010, P <.05) and internalized homophobia (β =.17; t = 2.07, P <.05) were significant predictors of suicidal ideation. Furthermore, perceived family support was found to moderate the relationship between minority stressors and suicidal ideation, such that individuals with higher levels of perceived family support experienced lower levels of suicidal ideation in response to minority stressors. The findings indicate that tackling minority stressors and enhancing perceived family support could be crucial strategies for lowering suicidal ideation among gender and sexual minorities. The study's outcomes have significant implications for creating interventions and programs focused on improving the mental health and well-being of gender and sexual minorities.