Background: Metabolic Syndrome (MetS) is a cluster of interrelated metabolic abnormalities, including central obesity, dyslipidemia, hypertension, and hyperglycemia, which increase the risk of cardiovascular disease, type 2 diabetes, and overall mortality. This study aimed to assess the prevalence of MetS among adolescents aged 13–19 years in the Akwapem North Municipality, Ghana. Methods: A descriptive cross-sectional study was conducted with 184 students from Presbyterian Senior High School, Mampong Akwapem. Participants were selected using stratified random sampling. Data were collected through questionnaires, anthropometric measurements (height, weight, waist circumference), blood pressure measurements, and biochemical assessments of fasting blood glucose, triglycerides, HDL cholesterol, and LDL cholesterol. The data were analyzed using STATA version 18. Results: The prevalence of MetS among participants was 6.52% (95% CI: 3.73% – 11.17%). The most common metabolic abnormalities were low HDL cholesterol (46.74%) and elevated triglycerides (7.61%). The prevalence of elevated blood pressure (1.63%) and high fasting glucose (5.98%) were comparatively lower. A statistically significant association was found between BMI category and MetS (p<0.001), with overweight and obese participants showing a higher prevalence. Waist circumference also demonstrated a significant association with MetS (p<0.001). Conclusion: The prevalence of MetS among adolescents in the Akwapem North Municipality is concerning, highlighting the need for early detection and intervention. The findings suggest that excess body weight and abdominal obesity are significant determinants of MetS in this population. Public health strategies, including routine screening, health education, and lifestyle interventions, are essential for addressing the rising prevalence of MetS and preventing longterm health complications.