Medicines called antibiotics are used to treat or stop bacterial infections. They have the ability to either eradicate or stop the growth of germs. This historical review's objective is to present data regarding the development and application of antibiotic formulations across time. Examine the following methods: The study material included pertinent texts and scientific papers on the topic, including those listed in the literature for this investigation. Findings: Antibiotics were initially used more than 2,500 years ago by the ancient Chinese. Chinese people employed moldy soybeans to treat furuncles (pimples), carbuncles, and other related ailments after learning about their medicinal qualities. Scottish pharmacologist and biologist Sir Alexander Fleming worked in the fields of immunology, bacteriology, and chemotherapy. He and Florey and Chain were awarded the 1945 Nobel Prize in Physiology and Medicine for their discovery of the first antibiotic, penicillin, in 1928. Conclusions: The antibiotic gradually became the medication of choice. The advantage of modern therapy is the availability of safe and effective antibiotic compositions