This study was anchored on Tackle Prostate Cancer Media Campaign and Health Behaviour of Men in South-East Nigeria. The objectives of the study were to find out the extent South-East Nigerian men access media information on tackle prostate cancer, find out the extent to which media promote campaign on tackle prostate cancer amongst men in South-East Nigeria, examine which of the media channels that South-East Nigerian men mostly use in getting information on tackle prostate cancer, ascertain the extent to which the media campaign on Tackle prostate cancer affect the health behaviour of men in South-East Nigeria, unravel the challenges associated with the media campaign on tackle prostate cancer amongst South-East Nigerian men and identify the ways in which the challenges can be handled. The study adopted framing and social judgment theories. The study also adopted triangulation method with questionnaire and interview as instruments for data collection. The sample size was made up of 385 respondents, out of a population of 5,068,566. Multi-stage sampling technique was adopted for the study. The major findings revealed that there is a high level of regularity in media access to information to tackle prostate cancer, awareness of media campaign about the tackle of prostate cancer, and their accessibilities to messages about prostate cancer. It was also revealed that there is a high level of interest in getting more media information about tackle of prostate cancer. It was concluded that media campaign on tackle prostate cancer and sensitization of health benefits is a serious campaign both on Social media, electronic and print. This is because of the high level of spread of the ailment and its deadly and severe painful nature. It is therefore recommended that South-East Nigeria men and beyond should endeavour to seek and access information about prostate cancer in order to be updated about the ailment as well as preventing and remedying the situation.