As cloud computing becomes increasingly prevalent, ensuring robust information security is essential to protect sensitive data from evolving cyber threats, especially in shared cloud infrastructures where unique vulnerabilities arise. This study aims to explore the impact of information security on cloud computing through a systematic literature review of articles sourced from reputable databases such as Science Direct, Emerald Insight, MDPI, and Taylor & Francis. The findings highlight that cloud security is anchored in securing systems, infrastructure, user authentication, and networks. Advanced techniques like the Attack Defense Model, Graph Neural Networks, and Homomorphic Encryption are used to address threats, while user behavior and strong architectural designs are critical factors. Continuous evaluation and anomaly detection further enhance security in cloud environments. This research contributes to understanding the relationship between information security and cloud computing, offering practical strategies for organizations and cloud service providers to mitigate risks, build trust, and ensure data protection in the cloud.